The C&O ran along the River, from Ashland to Covington.
The L&N ran to Paris, and beyond.

 

C&O Depot, in the 1913 (?) flood
from a Facebook post by Leland Pollitt

The Old C&O Depot, Maysville	C  & O Depot	The Old C&O Depot, Maysville
Before being used as a depot, it was the C. B. Pearce home, and was acquired for the depot on June 22, 1887.

 

The view is of the rear of this home that served as the C&O's depot.

 

The old C & O Depot in the Snow	The old C & O Depot in the Snow	C & O Depot in the 1913 Flood

 

The “C & O Viaduct,” c. WWI

 

C&O runs Oligonunk Excursions.
Oligonunk?!?! Wikipedia knows.

 

A crossing gate on the C&O, where a man was stationed to be able to alert folks a train was about to pass.

 

Maysville Bridge,  looking toward town.	Pumphouse Construction,  circa 1925	C & O Coal Docks, Maysville From the collection of the Public Library of Cincinnati and Hamilton County

"Work is to begun at once by the Chesapeake & Ohio in the erection of large coal docks at Maysville, Ky., in order that the increasing demands of the road may be accommodated.  The material for these docks is now on the ground and the works of construction will be begun in a few days.  The docks are to be built for the purpose of facilitating the work of coaling locomotives.  When the new coaling station is completed it will be one of the largest along the line of the C. & O.  Some time ago the Chesapeake & Ohio acquired a considerable parcel of land east of Maysville, Ky., and it is upon this property that the new coal docks are to be built.  The materials to be used in the construction of the docks will be wood, iron and steel."        from Fuel Magazine: The Coal Operators Weekly, 1910

“The C. &O. coal docks, which cost the company about $50,000 several years ago, situated just at the eastern outskirts of the city, to-day were transferred to Concord, fifteen miles above.  Several months ago the docks were burned, and the company decided to rebuild at a more convenient place.  The change causes a loss of more than $2,000 per month in salaries in Maysville.”  From the Louisville Courier Journal, June 18, 1919

C & O Depot

 

C & O  Passenger Train	New C & O Depot, circa 1930. This became the depot on October 16, 1918.  Story's here.	New C & O Depot, circa 1958.	President Eisenhower's Funeral Train passes thru Maysville, April 1, 1969

If you have an interest in steam and diesel locomotives of the Chesapeake and Ohio,
images of which may or may not have been taken in this area are here.

Local Freight	Freight Depot

 

The Maysville & Big Sandy
a forerunner to the C & O.

Inside the depot	The C&O interlocking tower controlled the rail sidings for Carnation, Brownings, and the tobacco warehouses. 1984.		At the freight station, 1976.
Great images from David Tuel Facebook posts

 

C&O engine #79 had her boiler explode, May 20, 1899 Details.		A sleeper goes over, near Lawrence Creek, 1907

 

1963 Train wreck. From a Facebook post by Dottie Caproni of pictures from Jimmy Ray King

 

C. & O. 7047, and EMD F7A, in 1951 Taken near Springfield, Ill.	C. & O. 4002, an Unit, in 1963 Taken near Newport News,Va.

TTI in Maysville, October, 1982

“A locomotive on the Chesapeake and Ohio Railroad that pulls the Maysville and Cincinnati accommodation train, bursted its boiler, on May 20th, just after its arrival in Maysville, Ky.  Alfred Maddox, the engineer, was sitting in the cab at the time. He was thrown fifty feet and received injuries from which it is believed that he can not recover.  The bell of the locomotive and pieces of the boiler were found a quarter of a mile away.”Locomotive, Vol. 19-20, 1898.
By 1911, the C&O was double-track, virtually all the way from Maysville to Cincinnati.	The first Pullman's (Wikipedia) came to Maysville on July 10, 1889.
Rate war between the C&O and the riverboats.	There was trouble during the construction of the railroad.
An account of a 1907 train wreck in Maysville is here.	There's also an account of a train wreck from 1890, here, and a follow-up, here.
Both the C&O and the L&N  have on-line  historical societies.  The L&N's is here; and the C&O's  is here.